ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Prof. Peter Reiss
The Academic Medical Center (AMC) of the University of Amsterdam is one of the foremost research institutions in the Netherlands, as well as one of its largest hospitals. The AMC accommodates a team of clinical, basic and translational researchers who, with the additional expertise of other partners and consortium members, jointly have the unique complementary expertise and experience to contribute to the successful execution of the work described in this project. The Amsterdam Institute for Global Health and Development (AIGHD) Foundation, specifically established by the AMC to carry out and manage global health-related research projects particularly in an international context, has the necessary expertise and experience to scientifically coordinate and administer the project in accordance with European Commission requirements.
IMPERIAL COLLEGE LONDON
Dr. Alan Winston
Imperial College London in conjunction with Imperial Heathcare NHS Trust created the UK’s first
Academic Health Science Centre (AHSC). The AHSC brings together the delivery of healthcare services, teaching and research in a partnership which values rigorous enquiry and evidence-based decisions, leading to the best healthcare for patients. This institution has expertise in running international HIV clinical trials and is a world leading center in neuro-imaging research.
Prof. Magnus Gisslén
Göteborgs Universitet is one of the major universities in Northern Europe. The University’s roughly 40 different departments cover most scientific disciplines. The Sahlgrenska Academy is the faculty of health sciences at Göteborgs Universitet. Education and research are conducted within the fields of pharmacy, medicine, odontology and health care sciences. The Department of Infectious Diseases at Göteborgs Universitet will be responsible for leading WP5 and contribute in measuring biomarkers of neuronal damage and inflammation.
UNIVERSITY COLLEGE LONDON
Prof. Caroline Sabin
UCL (University College London) is a large multidisciplinary university. UCL is one of Europe’s largest centres for biomedical science, interacting with eleven major London hospitals. The HIV Epidemiology and Biostatistics Group (HEBG), within the Department of Infection and Population Health, consists of a large group of statisticians and epidemiologists working on HIV infection (the largest such group in the UK). The group has made major contributions through the analysis of large collaborative national and international cohorts, to describing the impacts of multi-drug anti-HIV therapy and understanding its underlying mechanisms of action.
STICHTING KATHOLIEKE UNIVERSITEIT
Prof. David Burger
The Radboud University Nijmegen Medical Center (Stichting Katholieke Universiteit) is one of 8 academic medical centers in The Netherlands. Scientific research is organised in 6 research institutes of which the Nijmegen Institute for Infection, Inflammation and Immunity (N4i) is one. This partner will be responsible for leading the Pharmacological studies both in animals (WP4) and the clinical cohort (WP2&3). Stichting Katholieke Universiteit will advise on design, conductance and analyses of these studies, especially in terms of drugs and drug doses to be selected. Furthermore, pharmacokinetic (PK) studies will be conducted both in HIS mice and in the clinical cohort.
ALMA MATER STUDIORUM UNIVERSITÁ DI BOLOGNA
Prof. Claudio Franceschi
The University of Bologna (UNIBO), the oldest University in Europe and one of the largest in Italy, ranks at top levels in several disciplines. The Laboratory of Immunology led by Prof. Claudio Franceschi is 500m2 fully equipped for genetics, epigenetics, cell and molecular biology studies. Prof. Claudio Franceschi pioneered the field of the biological basis of human ageing and longevity by proposing centenarians as a model of successful aging and identified the major characteristics of immunosenescence, and a variety of genetic variants, including mtDNA, associated with successful (centenarians and their offspring, long living sibpairs) and unsuccessful ageing and age-related diseases (Alzheimer’s disease,T2DM).
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Prof. Jan Hoeijmakers
The Genetics department of the Erasmus Univ. Medical Centre is one of the leading centres in the world regarding research on DNA damage repair and signalling and its medical and biological impact for organisms (including mammals). The multi-disciplinary research led to one of its key discoveries that disclosed the role for specific DNA lesions as a causal factor for (accelerated) aging. The Department has ample experience in analyzing (accelerated) aging at both the organismal, cellular and molecular level using a wide variety of state-of-the-art ‘-omics’ and advanced imaging technologies.
Prof. Claude Libert
VIB is a centre of excellence comprising 800 scientists in 70 groups performing frontline research in life sciences and focusing on the fundamental understanding of growth, development and diseases.
VIB has successfully coordinated or participated in several EU projects, including Human Mobility projects, and two VIB laboratories were selected as training centers. In the VIB Department for Molecular Biomedical Research (DMBR), more than 150 scientists work in diverse fields of biotechnology, development, oncology, and inflammation biology. Analyzing the N-glycan profile of the serum and CSF of HIV-infected patients could teach us if their aging process is accelerated compared to controls, and whether they are prone to age-related disease, especially neurological disease.
Prof. Maria Prins
The Public Health Service Amsterdam (PHS, or GGD) is a largely public funded organization founded at the end of the 19th century. It’s main mission is improving and implementing public health
programmes in Amsterdam and vicinity. The research department within the Cluster of Infectious
Diseases (150 employees) aims to control and prevent the spread of infectious diseases. Research is an important component of the Cluster’s activities and is focused in on infectious disease epidemiology, in particular on HIV, viral hepatitis, STI, travel related infections and human papilloma virus infections. Several other new cohort studies have been initiated including the AgehIV cohort study which importantly contributes to the COBRA project. HIV negative controls for the COBRA cohort in Amsterdam are recruited and followed at the PHS site.
UNIVERSITÁ DEGLI STUDI DI MODENA E REGGIO EMILIA
Dr. Giovanni Guaraldi
The Infectious Disease Clinic is part of the Department of Medicine, Emergency Medicine and Medical Specialties. Its missions include: clinical activities, education and research. Clinical activity is provided at Policlinico University Hospital by a medical ward of 27 beds, an HIV out-patients clinic
(serving 1500 HIV infected patients), an Hepatitis clinic (serving 800 patients) and a Metabolic Clinic.
The latter is a third level multidisciplinary centre, founded in 2000 by Dr. Guaraldi, assessing Age
Associated Non Communicable Co-Morbidities (AANCC) for HIV infected patients. In this clinic more than 4000 HIV people are referred from all over Italy and prospectively followed up once a year, to receive, free of charge, infectious disease physicians, nutritionists, psychiatrist, cardiologist, nephrologists, endocrinologists and plastic surgeons consultation.
STICHTING HIV MONITORING
Dr. Sima Zaheri
Stichting HIV Monitoring (SHM), the Dutch HIV monitoring Foundation, makes an important and necessary contribution to healthcare for HIV-infected people living in the Netherlands. Through the collection and maintenance of anonymous data from HIV patients throughout the country, SHM’s work contributes significantly to the knowledge of HIV and enables treating physicians to assess and improve patient care. Research conducted by SHM results in tangible advice geared to medical professionals and patients, government and healthcare at large. Results of SHM’s research and those of others are presented regularly in medical journals and at international meetings and conferences. Furthermore, SHM delivers contributions to global HIV research.
Prof. Alexander Bürkle
The University of Konstanz (UKON) is renowned for its research at the international level and is currently ranked as one out nine top-level universities in Germany. Scientific research is organised in 3 Faculties. The Dept of Biology is part of the Science Faculty and comprises about 30 research groups, including the group headed by Prof Alexander Bürkle. The scientific focus of the group is in DNA repair research and biomarkers of ageing. Alexander Bürkle is the coordinator of the ongoing FP7 integrated project MARK-AGE.